PLASMA FENTANYL CONCENTRATIONS DURING TRANSDERMAL DELIVERY OF FENTANYL TO SURGICAL PATIENTS
نویسندگان
چکیده
منابع مشابه
Plasma fentanyl concentrations during transdermal delivery of fentanyl to surgical patients.
Plasma fentanyl concentrations were measured during and after transdermal fentanyl delivery in groups of patients undergoing general surgery. At 8 and 12 h, concentrations did not differ from those observed in a matched group of patients receiving fentanyl by i.v. infusion. At 24 h, concentrations were significantly lower in one of the transdermal groups. Plasma fentanyl clearance did not diffe...
متن کاملUrine concentrations of fentanyl and norfentanyl during application of Duragesic transdermal patches.
A study of the urinary concentration of fentanyl (F) and its major metabolite norfentanyl (NF) in chronic pain patients treated with the Duragesic continuous release transdermal patches is presented. These patches are available in 10, 20, 30, and 40 cm(2) sizes releasing 25, 50, 75, and 100 microg/h F, respectively. F is rapidly and extensively metabolized, with NF as the major metabolite. Five...
متن کاملFentanyl sublingual spray for breakthrough cancer pain in patients receiving transdermal fentanyl.
AIM To investigate the relationship between effective fentanyl sublingual spray (FSS) doses for breakthrough cancer pain (BTCP) and around-the-clock (ATC) transdermal fentanyl patch (TFP). METHODS Adults tolerating ATC opioids received open-label FSS for 26 days, followed by a 26-day double-blind phase for patients achieving an effective dose (100-1600 µg). RESULTS Out of 50 patients on ATC...
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The introduction of a transdermal delivery system for fentanyl means that it is now more readily available. We present the first documented fatality after intravenous injection of the contents of a transdermal fentanyl patch. Prescribers need to be aware of the potential for misuse of fentanyl patches.
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1. Balki M, Manninen PH. Craniotomy for suprasellar meningioma in a 28-week pregnant woman without fetal heart rate monitoring. Can J Anesth 2004;51:573-6. 2. Chow MS, Mercier PA, Omahen DA, Wood SL, Johnson JA. Recurrent exophytic meningioma in pregnancy. Obstet Gynecol 2013;121:475-8. 3. Rodríguez-Porcel F, Hughes I, Anderson D, Lee J, Biller J. Foster kennedy syndrome due to meningioma growt...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1988
ISSN: 0007-0912
DOI: 10.1093/bja/60.6.614